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Title: Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes
Authors: Oláh, Attila
Tóth, Balázs István
Borbíró, István
Sugawara, Koji
Szöllõsi, Attila G
Czifra, Gabriella
Pál, Balázs
Ambrus, Lídia
Kloepper, Jennifer
Camera, Emanuela
Ludovici, Matteo
Picardo, Mauro
Voets, Thomas
Zouboulis, Christos C
Paus, Ralf
Bíró, Tamás # ×
Issue Date: Sep-2014
Publisher: American Society for Clinical Investigation
Series Title: Journal of Clinical Investigation vol:124 issue:9 pages:3713-3724
Article number: 64628
Abstract: The endocannabinoid system (ECS) regulates multiple physiological processes, including cutaneous cell growth and differentiation. Here, we explored the effects of the major nonpsychotropic phytocannabinoid of Cannabis sativa, (-)-cannabidiol (CBD), on human sebaceous gland function and determined that CBD behaves as a highly effective sebostatic agent. Administration of CBD to cultured human sebocytes and human skin organ culture inhibited the lipogenic actions of various compounds, including arachidonic acid and a combination of linoleic acid and testosterone, and suppressed sebocyte proliferation via the activation of transient receptor potential vanilloid-4 (TRPV4) ion channels. Activation of TRPV4 interfered with the prolipogenic ERK1/2 MAPK pathway and resulted in the downregulation of nuclear receptor interacting protein-1 (NRIP1), which influences glucose and lipid metabolism, thereby inhibiting sebocyte lipogenesis. CBD also exerted complex antiinflammatory actions that were coupled to A2a adenosine receptor-dependent upregulation of tribbles homolog 3 (TRIB3) and inhibition of the NF-κB signaling. Collectively, our findings suggest that, due to the combined lipostatic, antiproliferative, and antiinflammatory effects, CBD has potential as a promising therapeutic agent for the treatment of acne vulgaris.
URI: 
ISSN: 0021-9738
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Ion Channel Research
× corresponding author
# (joint) last author

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