Title: Antiretroviral activity of metal-chelating HIV-1 integrase inhibitors
Authors: Carcelli, Mauro ×
Rogolino, Dominga
Sechi, Mario
Rispoli, Gabriele
Fisicaro, Emilia
Compari, Carlotta
Grandi, Nicole
Corona, Angela
Tramontano, Enzo
Pannecouque, Christophe
Naesens, Lieve #
Issue Date: Aug-2014
Series Title: European Journal of Medicinal Chemistry vol:83 pages:594-600
Article number: S0223-5234(14)00584-4
Abstract: Data regarding the activity of metal complexes against HIV virus in cell are surprisingly scarce. In this study, we present the antiviral activity against HIV-infected cells of different types of chelating ligands and of their metal complexes. In particular, the carboxamide chelating scaffold and the corresponding coordination compounds demonstrated an interesting antiviral profile in the nanomolar range. These molecules inhibit not only HIV integrase catalytic activity, but they also interfere with the function of the RNase H component of the HIV reverse transcriptase. Here we also discuss the thermodynamic characterization in solution of the metal complexes of the most active ligands, affording to the best of our knowledge for the first time this type of data for complexes with anti-HIV activity.
ISSN: 0223-5234
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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