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Title: Micro-drive array for chronic in vivo recording: drive fabrication
Authors: Kloosterman, Fabian ×
Davidson, Thomas J
Gomperts, Stephen N
Layton, Stuart P
Hale, Gregory
Nguyen, David P
Wilson, Matthew A #
Issue Date: 2009
Series Title: Journal of visualized experiments : JoVE issue:26
Article number: 10.3791/1094
Abstract: Chronic recording of large populations of neurons is a valuable technique for studying the function of neuronal circuits in awake behaving rats. Lightweight recording devices carrying a high density array of tetrodes allow for the simultaneous monitoring of the activity of tens to hundreds of individual neurons. Here we describe a protocol for the fabrication of a micro-drive array with twenty one independently movable micro-drives. This device has been used successfully to record from hippocampal and cortical neurons in our lab. We show how to prepare a custom designed, 3-D printed plastic base that will hold the micro-drives. We demonstrate how to construct the individual micro-drives and how to assemble the complete micro-drive array. Further preparation of the drive array for surgical implantation, such as the fabrication of tetrodes, loading of tetrodes into the drive array and gold-plating, is covered in a subsequent video article.
URI: 
ISSN: 1940-087X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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