BRCA1 gene promoter methylation status in high-grade serous ovarian cancer patients - A study of the tumour Bank ovarian cancer (TOC) and ovarian cancer diagnosis consortium (OVCAD)
Ruscito, I × Vasconcelos, I Gellhaus, K Schwachula, T Bellati, F Zeillinger, R Benedetti-Panici, P Vergote, Ignace Mahner, S Cacsire-Tong, D Concin, N Darb-Esfahani, S Lambrechts, S Sehouli, J Olek, S Braicu, E I #
European Journal of Cancer vol:50 issue:12 pages:2090-8
Mutations in BRCA1/2 genes are involved in the pathogenesis of breast and ovarian cancer. Inactivation of these genes can also be mediated by hypermethylation of CpGs in the promoter regions. Aim of this study was to analyse the clinical impact of BRCA1 promoter gene methylation status in a homogenous cohort of high-grade serous ovarian cancer (HGSOC) patients.