Title: Development of a Universal Anti-Adalimumab Antibody Standard for Interlaboratory Harmonization
Authors: Gils, Ann * ×
Vande Casteele, Niels *
Poppe, Raf
Van de Wouwer, Marlies
Compernolle, Griet
Peeters, Miet
Brouwers, Els
Vermeire, Severine
Geukens, Nick
Declerck, Paul #
Issue Date: Oct-2014
Publisher: Raven Press
Series Title: Therapeutic Drug Monitoring vol:36 issue:5 pages:669-73
Abstract: Therapeutic drug monitoring of adalimumab (ADM) has been introduced recently. When no detectable ADM serum concentrations can be found, the formation of antidrug antibodies (ADA) should be investigated. A variety of assays to measure the occurrence of ADA have been developed. Results are expressed as arbitrary units or as a titration value. The aim was to develop a monoclonal antibody (MA) that could serve as a universal calibrator to quantify the amount of ADA in ADM-treated patients.
ISSN: 0163-4356
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Therapeutic and Diagnostic Antibodies (+)
Translational Research in GastroIntestinal Disorders
Chemistry, Campus Kulak Kortrijk
Chemistry - miscellaneous
* (joint) first author
× corresponding author
# (joint) last author

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