Title: Cytokine balance and cytokine-driven natural killer cell dysfunction in systemic juvenile idiopathic arthritis
Authors: Avau, Anneleen
Put, Karen
Wouters, Carine
Matthys, Patrick # ×
Issue Date: Feb-2015
Publisher: Elsevier Science
Series Title: Cytokine & Growth Factor Reviews vol:26 pages:35-45
Article number: S1359-6101(14)00047-1
Abstract: Systemic juvenile idiopathic arthritis (sJIA) is a severe inflammatory childhood disorder, characterized by a specific pattern of systemic features and a typical cytokine profile. Patients are at risk to develop macrophage activation syndrome (MAS), an acute life-threatening condition defined by excessive proliferation and activation of macrophages and T cells. Defects of unknown cause in the natural killer (NK) cell cytotoxic capacity are presumed to underlie the pathogenesis of MAS and have been detected in sJIA patients. Here, we provide an overview of the cytokine profiles in sJIA and related mouse models. We discuss the influence of cytokines on NK cell function, and hypothesize that NK cell dysfunction in sJIA is caused by altered cytokine profiles.
ISSN: 1359-6101
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Pediatric Immunology
Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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