Title: What do we really know and what do we need to know: some controversies, perspectives, and surprises
Authors: Nilius, Bernd ×
Flockerzi, Veit #
Issue Date: 2014
Series Title: Handbook of experimental pharmacology vol:223 pages:1239-80
Article number: 10.1007/978-3-319-05161-1_20
Abstract: TRP channels comprise one of the most rapid growing research topics in ion channel research, in fields related to ion channels including channelopathies and translational medicine. We provide here a critical survey on our current knowledge of TRP channels and highlight some of the still open or controversial questions. This comprises questions related to evolution of TRP channels; biophysics, i.e., permeation; pore properties and gating; modulation; the still-elusive 3D structure; and channel subunits but also their role as general sensory channels and in human diseases. We will conclude that our knowledge on TRP channels is still at the very beginning of an exciting research journey.
ISSN: 0171-2004
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Cellular and Molecular Medicine - miscellaneous
× corresponding author
# (joint) last author

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