Title: Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis
Authors: Verbeek, Jef ×
Lannoo, Matthias
Pirinen, Eija
Ryu, Dongryeol
Spincemaille, Pieter
Vander Elst, Ingrid
Windmolders, Petra
Thevissen, Karin
Cammue, Bruno
van Pelt, Jos
Fransis, Sabine
Van Eyken, Peter
Ceuterick-De Groote, Chantal
Van Veldhoven, Paul P
Bedossa, Pierre
Nevens, Frederik
Auwerx, Johan
Cassiman, David #
Issue Date: Apr-2015
Publisher: BMJ Publishing Group
Series Title: Gut vol:64 issue:4 pages:673-683
Article number: gutjnl-2014-306748
Abstract: No therapy for non-alcoholic steatohepatitis (NASH) has been approved so far. Roux-en-y gastric bypass (RYGB) is emerging as a therapeutic option, although its effect on NASH and related hepatic molecular pathways is unclear from human studies. We studied the effect of RYGB on pre-existent NASH and hepatic mitochondrial dysfunction-a key player in NASH pathogenesis-in a novel diet-induced mouse model nicely mimicking human disease.
ISSN: 0017-5749
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hepatology
Centre of Microbial and Plant Genetics
Department of Imaging & Pathology - miscellaneous
Laboratory of Lipid Biochemistry and Protein Interactions
× corresponding author
# (joint) last author

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