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Title: Soluble urokinase receptor is a biomarker of cardiovascular disease in chronic kidney disease
Authors: Meijers, Bj√∂rn ×
Poesen, Ruben
Claes, Kathleen
Dietrich, Ruth
Bammens, Bert
Sprangers, Ben
Naesens, Maarten
Storr, Markus
Kuypers, Dirk
Evenepoel, Pieter #
Issue Date: Jan-2015
Publisher: Nature Pub. Group
Series Title: Kidney International vol:87 issue:1 pages:210-6
Article number: 10.1038/ki.2014.197
Abstract: Soluble urokinase-type plasminogen activator receptor (suPAR) accumulates in patients with chronic kidney disease (CKD). In various non-CKD populations, suPAR has been proposed as a prognostic marker for mortality and cardiovascular disease. However, it is not known whether suPAR holds prognostic information in patients with mild-to-moderate CKD. In a prospective observational study of 476 patients with mild-to-moderate kidney disease, we examined multivariate associations between suPAR, overall mortality, and cardiovascular events. After a mean follow-up of 57 months, 52 patients died and 76 patients had at least one fatal or nonfatal cardiovascular event. Higher suPAR was directly and significantly associated with both overall mortality (univariate hazard ratio 5.35) and cardiovascular events (univariate hazard ratio 5.06). In multivariate analysis, suPAR remained significantly associated with cardiovascular events (full model, hazard ratio 3.05). Thus, in patients with mild-to-moderate CKD, suPAR concentrations show a clear, direct, and graded association with a higher risk for new-onset cardiovascular disease.Kidney International advance online publication, 4 June 2014; doi:10.1038/ki.2014.197.
ISSN: 0085-2538
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Nephrology
Laboratory of Experimental Transplantation
× corresponding author
# (joint) last author

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