Preoperative oxaliplatin, capecitabine, and external beam radiotherapy in patients with newly diagnosed, primary operable, cT₃NxM0, low rectal cancer: a phase II study
Ofner, Dietmar × Devries, Alexander F Schaberl-Moser, Renate Greil, Richard Rabl, Hans Tschmelitsch, Jörg Zitt, Matthias Kapp, Karin S Fastner, Gerd Keil, Felix Eisterer, Wolfgang Jäger, Robert Offner, Felix Gnant, Michael Thaler, Josef TAKO 05/ABCSG R-02 Trial Investigators Bechter, Oliver #
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] vol:187 issue:2 pages:100-7
In patients with locally advanced rectal cancer (LARC), preoperative chemoradiation is known to improve local control, and down-staging of the tumor serves as a surrogate for survival. Intensification of the systemic therapy may lead to higher downstaging rates and, thus, enhance survival. This phase II study investigated the efficacy and safety of preoperative capecitabine and oxaliplatin in combination with radiotherapy.