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Title: Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran
Authors: Tsirkone, Vicky
Beutels, Katrien
Demeulemeester, Jonas
Debyser, Zeger
Christ, Frauke
Strelkov, Sergei # ×
Issue Date: 24-May-2014
Publisher: Wiley-blackwell publishing, inc
Series Title: Acta Crystallographica F, Structural Biology and Crystallization Communications Online vol:70 issue:6 pages:723-729
Abstract: Transportin SR2 (TRN-SR2) is a -type karyopherin responsible for the nuclear
import of specific cargoes, including serine/arginine-rich splicing factors. The
protein has been implicated in a variety of human diseases, including HIV
infection, primary biliary cirrhosis and limb-girdle muscular dystrophy 1F.
Towards understanding its molecular mechanism, a 2.9 A ˚ resolution crystal
structure of human TRN-SR2 complexed with the small GTPase Ran has been
determined. TRN-SR2 is composed of 20 -helical HEAT repeats forming a
solenoid-like fold. The first nine repeats form a ‘cradle’ for the binding of
RanGTP, revealing similarities but also differences with respect to the related
importin 13 complex.
ISSN: 1744-3091
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biocrystallography
Molecular Virology and Gene Therapy
× corresponding author
# (joint) last author

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