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Title: Magnetic Resonance Imaging for Noninvasive Assessment of Lung Fibrosis Onset and Progression: Cross-Validation and Comparison of Different Magnetic Resonance Imaging Protocols With Micro-Computed Tomography and Histology in the Bleomycin-Induced Mouse Model
Authors: Vande Velde, Greetje
De Langhe, Ellen
Poelmans, Jennifer
Dresselaers, Tom
Lories, Rik #
Himmelreich, Uwe # ×
Issue Date: Nov-2014
Publisher: J.B. Lippincott
Series Title: Investigative Radiology vol:49 issue:11 pages:691-8
Abstract: Bleomycin instillation is frequently used to model lung fibrosis, although the onset and severity of pathology varies highly between mice. This makes non-invasive fibrosis detection and quantification essential to obtain a comprehensive analysis of the disease course and to validate novel therapies. Magnetic resonance imaging (MRI) of lung disease progression and therapy may provide such a sensitive in vivo readout of lung fibrosis, bypassing radiotoxicity concerns (when using micro-CT [μCT]) and elaborate invasive end point measurements (histology). We aimed to optimize and evaluate 3 different lung MRI contrast and acquisition methods to visualize disease onset and progression in the bleomycin-induced mouse model of lung fibrosis using a small-animal MRI scanner. For validation, we compared the MRI results with established μCT and histological measures of lung fibrosis.
ISSN: 0020-9996
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Skeletal Biology and Engineering Research Center (+)
Biomedical MRI
Rheumatology Section (-)
× corresponding author
# (joint) last author

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