Title: pH-responsive carrier system based on carboxylic acid modified mesoporous silica and polyelectrolyte for drug delivery
Authors: Yang, Q ×
Wang, SH
Fan, PW
Wang, LF
Di, Yan
Lin, KF
Xiao, FS #
Issue Date: Nov-2005
Publisher: American Chemical Society
Series Title: Chemistry of Materials vol:17 issue:24 pages:5999-6003
Abstract: An efficient pH-responsive carrier system has been constructed by oppositely charged ionic interaction between carboxylic acid modified SBA-15 silica rods and polyelectrolyte. Active molecules such as vancomycin can be stored and released from the pore voids of SBA-15 by changing pH values at will. The amount of vancomycin stored in the pores of sample based on carboxylic acid modified SBA-15 rods and poly(dimethyldiallylammonium chloride) is up to 36.4 wt % at pH 6.8. When the pH is at mild acidity, vancomycin is steadily released from the pores of SBA-15. Both nitrogen adsorption-desorption isothems and X-ray diffraction patterns show that this system possesses stable mesostructure, which will be considered an interesting alternative to a polymeric delivery system.
ISSN: 0897-4756
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre for Surface Chemistry and Catalysis
× corresponding author
# (joint) last author

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