Tijdschrift voor Geneeskunde vol:67 issue:16 pages:765-772
Carcinoid heart disease is a complication of a rare
syndrome caused by systemic spread of vaso-active
substances from tumoral metastases. Starting from an
interesting clinical case, we focus on histology, pathogenesis, diagnosis and treatment of carcinoid heart
disease. The pathogenesis is still poorly understood.
Historically serotonin was considered to be the causing
agent of fibrosis seen in carcinoid heart disease. Recently there has been a focus on other vaso-active substances and on growth factors. The combination of clinical findings, biochemistry and echocardiography is needed to achieve a diagnosis and prognosis. The current treatment mainly consists of somatostatine analogues and in selected cases valve surgery.