Title: Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study
Authors: van Doormaal, Perry T C ×
Ticozzi, Nicola
Gellera, Cinzia
Ratti, Antonia
Taroni, Franco
Chiò, Adriano
Calvo, Andrea
Mora, Gabriele
Restagno, Gabriella
Traynor, Bryan J
Birve, Anna
Lemmens, Robin
van Es, Michael A
Saris, Christiaan G J
Blauw, Hylke M
van Vught, Paul W J
Groen, Ewout J N
Corrado, Lucia
Mazzini, Letizia
Del Bo, Roberto
Corti, Stefania
Waibel, Stefan
Meyer, Thomas
Ludolph, Albert C
Goris, An
Van Damme, Philip
Robberecht, Wim
Shatunov, Aleksey
Fogh, Isabella
Andersen, Peter M
D'Alfonso, Sandra
Hardiman, Orla
Cronin, Simon
Rujescu, Dan
Al-Chalabi, Ammar
Landers, John E
Silani, Vincenzo
van den Berg, Leonard H
Veldink, Jan H #
Issue Date: Oct-2014
Publisher: Elsevier
Series Title: Neurobiology of Aging vol:35 issue:10 pages:2420.e13-4
Article number: S0197-4580(14)00316-9
Abstract: Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group.
ISSN: 0197-4580
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Neurobiology (Vesalius Research Center)
Laboratory for Neuroimmunology
× corresponding author
# (joint) last author

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