Title: Immunosuppression of experimental autoimmune myasthenia gravis by mycophenolate mofetil
Authors: Janssen, Sofie P M ×
Phernambucq, Marko
Martinez-Martinez, Pilar
De Baets, Marc H
Losen, Mario #
Issue Date: Sep-2008
Publisher: Elsevier/North Holland
Series Title: Journal of Neuroimmunology vol:201-202 pages:111-20
Abstract: Currently used non-specific immunosuppressive drugs often require intervention in myasthenia gravis (MG) and clinical improvement varies widely. To analyze the therapeutic effect of mycophenolate mofetil (MMF) in experimental autoimmune MG (EAMG), rats were immunized with acetylcholine receptors (AChRs) and subsequently treated with MMF or vehicle. MMF treatment resulted in a significant suppression of anti-rat AChR antibody titers. Interestingly, no abnormalities of neuromuscular transmission and adverse side effects were detected in MMF-treated EAMG animals. Moreover, anti-rat AChR antibody titers correlated to an improvement of clinical outcome. In conclusion, our data suggest that MMF acts as a potent immunosuppressant drug in EAMG.
ISSN: 0165-5728
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science