Safety of daily co-trimoxazole in pregnancy in an area of changing malaria epidemiology: a phase 3b randomized controlled clinical trial
Manyando, Christine × Njunju, Eric M Mwakazanga, David Chongwe, Gershom Mkandawire, Rhoda Champo, Davies Mulenga, Modest De Crop, Maaike Claeys, Yves Ravinetto, Raffaella van Overmeir, Chantal Alessandro, Umberto D' Van Geertruyden, Jean-Pierre #
Public Library of Sciene
PLoS One vol:9 issue:5 pages:e96017
Antibiotic therapy during pregnancy may be beneficial and impacts positively on the reduction of adverse pregnancy outcomes. No studies have been done so far on the effects of daily Co-trimoxazole (CTX) prophylaxis on birth outcomes. A phase 3b randomized trial was conducted to establish that daily CTX in pregnancy is not inferior to SP intermittent preventive treatment (IPT) in reducing placental malaria; preventing peripheral parasitaemia; preventing perinatal mortality and also improving birth weight. To establish its safety on the offspring by measuring the gestational age and birth weight at delivery, and compare the safety and efficacy profile of CTX to that of SP.