Title: Safety of daily co-trimoxazole in pregnancy in an area of changing malaria epidemiology: a phase 3b randomized controlled clinical trial
Authors: Manyando, Christine ×
Njunju, Eric M
Mwakazanga, David
Chongwe, Gershom
Mkandawire, Rhoda
Champo, Davies
Mulenga, Modest
De Crop, Maaike
Claeys, Yves
Ravinetto, Raffaella
van Overmeir, Chantal
Alessandro, Umberto D'
Van Geertruyden, Jean-Pierre #
Issue Date: 2014
Publisher: Public Library of Sciene
Series Title: PLoS One vol:9 issue:5 pages:e96017
Article number: 10.1371/journal.pone.0096017
Abstract: Antibiotic therapy during pregnancy may be beneficial and impacts positively on the reduction of adverse pregnancy outcomes. No studies have been done so far on the effects of daily Co-trimoxazole (CTX) prophylaxis on birth outcomes. A phase 3b randomized trial was conducted to establish that daily CTX in pregnancy is not inferior to SP intermittent preventive treatment (IPT) in reducing placental malaria; preventing peripheral parasitaemia; preventing perinatal mortality and also improving birth weight. To establish its safety on the offspring by measuring the gestational age and birth weight at delivery, and compare the safety and efficacy profile of CTX to that of SP.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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