Ambivalent role of pFAK-Y397 in serous ovarian cancer--a study of the OVCAD consortium
Aust, Stefanie × Auer, Katharina Bachmayr-Heyda, Anna Denkert, Carsten Sehouli, Jalid Braicu, Ioana Mahner, Sven Lambrechts, Sandrina Vergote, Ignace Grimm, Christoph Horvat, Reinhard Castillo-Tong, Dan Cacsire Zeillinger, Robert Pils, Dietmar #
Molecular Cancer vol:13 pages:67
Focal adhesion kinase (FAK) autophosphorylation seems to be a potential therapeutic target but little is known about the role and prognostic value of FAK and pFAK in epithelial ovarian cancer (EOC). Recently, we validated a gene signature classifying EOC patients into two subclasses and revealing genes of the focal adhesion pathway as significantly deregulated.