Title: Tuberculosis infection following anti-TNF therapy in inflammatory bowel disease, despite negative screening
Authors: Debeuckelaere, Celine ×
De Munter, Paul
Van Bleyenbergh, Pascal
De Wever, Walter
Van Assche, Gert
Rutgeerts, Paul
Vermeire, Severine #
Issue Date: Jun-2014
Publisher: Elsevier Science BV
Series Title: Journal of Crohns & Colitis vol:8 issue:6 pages:550-557
Article number: 10.1016/j.crohns.2013.11.008
Abstract: We present two patients with inflammatory bowel disease who, despite negative tuberculosis screening, developed a de novo tuberculosis infection after the start of anti tumor necrosis factor alpha treatment. We discuss current screening methods and their limitations, the approach after positive screening and the timing to resume anti-TNFα treatment after TB infection. We shortly mention the immune reconstitution inflammatory syndrome (IRIS), described in a few cases after the stop of anti-TNFalpha while treating the tuberculosis infection. We conclude with some remaining questions concerning tuberculosis in IBD patients.
ISSN: 1873-9946
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Clinical Infectious and Inflammatory Disorders
Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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