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Title: Invitro effect of interleukin-1-beta on human glioma cell-lines - regulation of cell-proliferation and il-6 production
Authors: Cinque, S ×
Willems, Jean
Depraetere, S
Vermeire, Lea
Joniau, Marcel #
Issue Date: 1992
Publisher: Elsevier science bv
Series Title: Immunology letters vol:34 issue:3 pages:267-271
Abstract: The human glioma cell lines U251 and HP591 were chosen as ''in vitro'' models for functional astrocytes. When cultured in the presence of IL-1beta these cell lines demonstrated a marked increase in interleukin-6 production and in [H-3]-thymidine uptake. The addition of dbcAMP could mimick the first effect of IL-1beta but at the same time suppressed cell proliferation. These results suggest that IL-1beta possibly exerts one of its biological effects (IL-6 synthesis) by means of the cyclic AMP pathway.
URI: 
ISSN: 0165-2478
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of Medicine, Campus Kulak Kortrijk
Mathematics, Campus Kulak Kortrijk
× corresponding author
# (joint) last author

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