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Title: Synthesis of a cluster-forming sialylthio-d-galactose fullerene conjugate and evaluation of its interaction with influenza virus hemagglutinin and neuraminidase
Authors: Tollas, Szilvia ×
Bereczki, Ilona
Borbás, Anikó
Batta, Gyula
Vanderlinden, Evelien
Naesens, Lieve
Herczegh, Pál #
Issue Date: Jun-2014
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:24 issue:11 pages:2420-3
Article number: 10.1016/j.bmcl.2014.04.032
Abstract: In order to obtain self assembling, multivalent ligand for influenza virus hemagglutinin α-N-acetylneuraminyl-(2-6)-d-galactopyranose has been synthesized and bonded to a water soluble fullerene derivative using 1,3-dipolar cycloaddition click reaction. The aggregating amphiphilic compound did not inhibit the influenza virus hemagglutinin, but it proved to be an inhibitor of its neuraminidase with a 50% inhibitory concentration of 81μM.
URI: 
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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