Title: Air travel is associated with intracontinental spread of dengue virus serotypes 1-3 in Brazil
Authors: Nunes, Marcio R T ×
Palacios, Gustavo
Faria, Nuno Rodrigues
Sousa, Edivaldo Costa
Pantoja, Jamilla A
Rodrigues, Sueli G
Carvalho, Valéria L
Medeiros, Daniele B A
Savji, Nazir
Baele, Guy
Suchard, Marc A
Lemey, Philippe
Vasconcelos, Pedro F C
Lipkin, W Ian #
Issue Date: Apr-2014
Publisher: Public Library Science
Series Title: PLoS Neglected Tropical Diseases vol:8 issue:4 pages:e2769
Article number: 10.1371/journal.pntd.0002769
Abstract: Dengue virus and its four serotypes (DENV-1 to DENV-4) infect 390 million people and are implicated in at least 25,000 deaths annually, with the largest disease burden in tropical and subtropical regions. We investigated the spatial dynamics of DENV-1, DENV-2 and DENV-3 in Brazil by applying a statistical framework to complete genome sequences. For all three serotypes, we estimated that the introduction of new lineages occurred within 7 to 10-year intervals. New lineages were most likely to be imported from the Caribbean region to the North and Northeast regions of Brazil, and then to disperse at a rate of approximately 0.5 km/day. Joint statistical analysis of evolutionary, epidemiological and ecological data indicates that aerial transportation of humans and/or vector mosquitoes, rather than Aedes aegypti infestation rates or geographical distances, determine dengue virus spread in Brazil.
ISSN: 1935-2735
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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