Title: Molecular mechanisms of antimicrobial tolerance and resistance in bacterial and fungal biofilms
Authors: Van Acker, Heleen ×
Van Dijck, Patrick
Coenye, Tom #
Issue Date: Jun-2014
Publisher: Elsevier Trends Journals
Series Title: Trends in Microbiology vol:22 issue:6 pages:326-33
Article number: S0966-842X(14)00024-9
Abstract: The formation of microbial biofilms is an important reason for failure of antimicrobial therapy. However, the molecular mechanisms underlying the survival of biofilm cells are still not completely understood. In this review we discuss three mechanisms that play an important role in biofilm survival: (i) biofilm-specific protection against oxidative stress; (ii) biofilm-specific expression of efflux pumps; and (iii) protection provided by matrix polysaccharides. We demonstrate that these mechanisms are found both in bacterial and fungal biofilms and are often surprisingly similar between distantly related organisms. In addition, we give an overview of the data that suggests that these mechanisms may not be independent.
ISSN: 0966-842X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Microbiology and Biotechnology Section - miscellaneous (-)
× corresponding author
# (joint) last author

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