Title: AGGRESCAN: method, application, and perspectives for drug design
Authors: de Groot, Natalia S
Castillo Cano, Virginia
Graña-Montes, Ricardo
Ventura, Salvador # ×
Issue Date: 2012
Publisher: Humana Press, Inc.
Series Title: Methods in Molecular Biology vol:819 pages:199-220
Article number: 10.1007/978-1-61779-465-0_14
Abstract: Protein aggregation underlies the development of an increasing number of conformational human diseases of growing incidence, such as Alzheimer's and Parkinson's diseases. Furthermore, the accumulation of recombinant proteins as intracellular aggregates represents a critical obstacle for the biotechnological production of polypeptides. Also, ordered protein aggregates constitute novel and versatile nanobiomaterials. Consequently, there is an increasing interest in the development of methods able to forecast the aggregation properties of polypeptides in order to modulate their intrinsic solubility. In this context, we have developed AGGRESCAN, a simple and fast algorithm that predicts aggregation-prone segments in protein sequences, compares the aggregation properties of different proteins or protein sets and analyses the effect of mutations on protein aggregation propensities.
ISSN: 1064-3745
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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