Title: Interleukin-6 dynamics as a basis for an early-warning monitor for sepsis and inflammation in individual pigs
Authors: Tambuyzer, Tim ×
De Waele, Tine
Chiers, Koen
Berckmans, Daniel
Goddeeris, Bruno
Aerts, Jean-Marie #
Issue Date: Jun-2014
Publisher: Harcourt
Series Title: Research in Veterinary Science vol:96 pages:460-463
Abstract: Static interleukin-6 (IL-6) levels of pigs contain considerable individual differences, which obstruct the practical use of IL-6 for disease monitoring purposes. It was hypothesised that interleukin-6 (IL-6) dynamics could be used to quantify these individual differences and carries critical information of the individual pig infection status. Time series of IL-6 responses in 25 pigs were analysed before and after infection by Actinobacillus pleuropneumoniae. The results indicated that amplitude increases of IL-6 fluctuations of individual pigs rather than static IL-6 values should be used as indicator of the infection state. This study shows the added value for IL-6 time series analyses of individual pigs. These results are a first step towards the development of objective individualised methods for monitoring and early detection of sepsis and inflammation processes in pigs by integrating animal response dynamics.
ISSN: 0034-5288
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division M3-BIORES: Measure, Model & Manage Bioresponses (-)
Division of Gene Technology (-)
× corresponding author
# (joint) last author

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