Soluble Jagged-1 inhibits neointima formation by attenuating Notch-Herp2 signaling
Caolo, Vincenza × Schulten, Henny M Zhuang, Zhen W Murakami, Masahiro Wagenaar, Allard Verbruggen, Sanne Molin, Daniel G M Post, Mark J #
Lippincott, Williams & Wilkins
Arteriosclerosis, Thrombosis and Vascular Biology vol:31 issue:5 pages:1059-65
Notch has been implicated in neointima formation as reflected by increased Notch/Jagged expression on vascular injury and the promigratory effect of Notch signaling on smooth muscle cells. Soluble Jagged-1 (sJag1) has been shown to inhibit Notch signaling in vitro; however, its capacity to suppress neointima formation remains unknown.