Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Medicine, General & Internal, Medicine, Research & Experimental, General & Internal Medicine, Research & Experimental Medicine, Cilia, diagnostic accuracy, fractional exhaled NO, nitric oxide, primary ciliary dyskinesia, sensitivity and specificity, CYSTIC-FIBROSIS, NASAL, CHILDREN, GUIDELINES, HEALTH, Adolescent, Adult, Breath Tests, Case-Control Studies, Child, Child, Preschool, Female, Humans, Kartagener Syndrome, Male, Nitric Oxide, Prospective Studies, Sensitivity and Specificity, Young Adult, 1103 Clinical Sciences, General Clinical Medicine, 3201 Cardiovascular medicine and haematology, 3202 Clinical sciences

Abstract:

Primary Ciliary Dyskinesia (PCD) is an orphan disease characterized by recurrent respiratory infections and an increased prevalence of situs inversus and male infertility. Low nasal Nitric Oxide (nNO) is used as a new test to diagnose PCD. The test sensitivity is good, but specificity has not been studied widely. Therefore, we evaluated the diagnostic accuracy of low nNO to diagnose PCD in a large cohort, including healthy patients and different disease controls.