Title: Inherited variation in the PARP1 gene and survival from melanoma
Authors: Davies, John R ×
Jewell, Rosalyn
Affleck, Paul
Anic, Gabriella M
Randerson-Moor, Juliette
Ozola, Aija
Egan, Kathleen M
Elliott, Faye
García-Casado, Zaida
Hansson, Johan
Harland, Mark
Höiom, Veronica
Jian, Guan
Jönsson, Göran
Kumar, Rajiv
Nagore, Eduardo
Wendt, Judith
Olsson, Håkan
Park, Jong Y
Patel, Poulam
Pjanova, Dace
Puig, Susana
Schadendorf, Dirk
Sivaramakrishna Rachakonda, P
Snowden, Helen
Stratigos, Alexander J
Bafaloukos, Dimitrios
Ogbah, Zighereda
Sucker, Antje
van den Oord, Joost
Van Doorn, Remco
Walker, Christy
Okamoto, Ichiro
Wolter, Pascal
Barrett, Jennifer H
Timothy Bishop, D
Newton-Bishop, Julia #
Issue Date: Oct-2014
Publisher: Wiley-Liss
Series Title: International Journal of Cancer vol:135 issue:7 pages:1625-33
Article number: 10.1002/ijc.28796
Abstract: We report the association of an inherited variant located upstream of the poly(adenosine diphosphate-ribose) polymerase 1 (PARP1) gene (rs2249844), with survival in 11 BioGenoMEL melanoma cohorts. The gene encodes a protein involved in a number of cellular processes including single-strand DNA repair. Survival analysis was conducted for each cohort using proportional hazards regression adjusting for factors known to be associated with survival. Survival was measured as overall survival (OS) and, where available, melanoma-specific survival (MSS). Results were combined using random effects meta-analysis. Evidence for a role of the PARP1 protein in melanoma ulceration and survival was investigated by testing gene expression levels taken from formalin-fixed paraffin-embedded tumors. A significant association was seen for inheritance of the rarer variant of PARP1, rs2249844 with OS (hazard ratio (HR) = 1.16 per allele, 95% confidence interval (CI) 1.04-1.28, p = 0.005, eleven cohorts) and MSS (HR = 1.20 per allele, 95% CI 1.01-1.39, p = 0.03, eight cohorts). We report bioinformatic data supportive of a functional effect for rs2249844. Higher levels of PARP1 gene expression in tumors were shown to be associated with tumor ulceration and poorer OS.
ISSN: 0020-7136
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science