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Title: Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity
Authors: Jiao, Yizu ×
Darzi, Youssef
Tawaratsumida, Kazuki
Marchesan, Julie T
Hasegawa, Mizuho
Moon, Henry
Chen, Grace Y
Núñez, Gabriel
Giannobile, William V
Raes, Jeroen
Inohara, Naohiro #
Issue Date: May-2013
Publisher: Cell Press
Series Title: Cell Host & Microbe vol:13 issue:5 pages:595-601
Article number: 10.1016/j.chom.2013.04.005
Abstract: Periodontitis is a common disease that is characterized by resorption of the alveolar bone and mediated by commensal bacteria that trigger host immune responses and bone destruction through unidentified mechanisms. We report that Nod1, an innate intracellular host receptor for bacterial peptidoglycan-related molecules, is critical for commensal-induced periodontitis in a mouse model. Mice lacking Nod1 exhibit reduced bone resorption as well as impaired recruitment of neutrophils to gingival tissues and osteoclasts to the alveolar bone, which mediate tissue and bone destruction. Further analysis showed that accumulation of a Nod1-stimulating commensal bacterium, NI1060, at gingival sites was sufficient to induce neutrophil recruitment and bone resorption. Genomic sequencing revealed that NI1060 is a mouse-specific bacterium that is related to bacteria associated with the development of aggressive periodontitis in humans. These findings provide insight into commensal-host interactions contributing to periodontitis and identify a potential target for preventing this common oral disease.
ISSN: 1931-3128
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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