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Title: Risk of Newly Detected Infections and Cervical Abnormalities in Women Seropositive for Naturally Acquired Human Papillomavirus Type 16/18 Antibodies: Analysis of the Control Arm of PATRICIA
Authors: Castellsagué, Xavier ×
Naud, Paulo
Chow, Song-Nan
Wheeler, Cosette M
Germar, Maria Julieta V
Lehtinen, Matti
Paavonen, Jorma
Jaisamrarn, Unnop
Garland, Suzanne M
Salmerón, Jorge
Apter, Dan
Kitchener, Henry
Teixeira, Julio C
Skinner, S Rachel
Limson, Genara
Szarewski, Anne
Romanowski, Barbara
Aoki, Fred Y
Schwarz, Tino F
Poppe, Willy
Bosch, F Xavier
de Carvalho, Newton S
Peters, Klaus
Tjalma, Wiebren A A
Safaeian, Mahboobeh
Raillard, Alice
Descamps, Dominique
Struyf, Frank
Dubin, Gary
Rosillon, Dominique
Baril, Laurence #
Issue Date: Aug-2014
Publisher: Published by the University of Chicago Press for the Infectious Diseases Society of America
Series Title: The Journal of Infectious Diseases vol:210 issue:4 pages:517-34
Abstract: Background. We examined risk of newly detected human papillomavirus (HPV) infection and cervical abnormalities in relation to HPV type 16/18 antibody levels at enrollment in PATRICIA (Papilloma Trial Against Cancer in Young Adults; NCT00122681).Methods. Using Poisson regression, we compared risk of newly detected infection and cervical abnormalities associated with HPV-16/18 between seronegative vs seropositive women (15-25 years) in the control arm (DNA negative at baseline for the corresponding HPV type [HPV-16: n = 8193; HPV-18: n = 8463]).Results. High titers of naturally acquired HPV-16 antibodies and/or linear trend for increasing antibody levels were significantly associated with lower risk of incident and persistent infection, atypical squamous cells of undetermined significance or greater (ASCUS+), and cervical intraepithelial neoplasia grades 1/2 or greater (CIN1+, CIN2+). For HPV-18, although seropositivity was associated with lower risk of ASCUS+ and CIN1+, no association between naturally acquired antibodies and infection was demonstrated. Naturally acquired HPV-16 antibody levels of 371 (95% confidence interval [CI], 242-794), 204 (95% CI, 129-480), and 480 (95% CI, 250-5756) EU/mL were associated with 90% reduction of incident infection, 6-month persistent infection, and ASCUS+, respectively.Conclusions. Naturally acquired antibodies to HPV-16, and to a lesser extent HPV-18, are associated with some reduced risk of subsequent infection and cervical abnormalities associated with the same HPV type.
URI: 
ISSN: 0022-1899
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Organ Systems (+)
Department of Health and Technology - UC Leuven
× corresponding author
# (joint) last author

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