Title: Neuronal control of metabolism through nutrient-dependent modulation of tracheal branching
Authors: Linneweber, Gerit
Jacobson, Jake
Busch, Karl Emanuel
Hudry, Bruno
Christov, Christo P
Dormann, Dirk
Yuan, Michaela
Otani, Tomoki
Knust, Elisabeth
de Bono, Mario
Miguel-Aliaga, Irene # ×
Issue Date: Jan-2014
Publisher: MIT Press
Series Title: Cell vol:156 issue:1-2 pages:69-83
Article number: 10.1016/j.cell.2013.12.008
Abstract: During adaptive angiogenesis, a key process in the etiology and treatment of cancer and obesity, the vasculature changes to meet the metabolic needs of its target tissues. Although the cues governing vascular remodeling are not fully understood, target-derived signals are generally believed to underlie this process. Here, we identify an alternative mechanism by characterizing the previously unrecognized nutrient-dependent plasticity of the Drosophila tracheal system: a network of oxygen-delivering tubules developmentally akin to mammalian blood vessels. We find that this plasticity, particularly prominent in the intestine, drives--rather than responds to--metabolic change. Mechanistically, it is regulated by distinct populations of nutrient- and oxygen-responsive neurons that, through delivery of both local and systemic insulin- and VIP-like neuropeptides, sculpt the growth of specific tracheal subsets. Thus, we describe a novel mechanism by which nutritional cues modulate neuronal activity to give rise to organ-specific, long-lasting changes in vascular architecture.
ISSN: 0092-8674
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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