Title: Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors
Authors: Kendel, Yvonne ×
Melaun, Christian
Kurz, Alexander
Nicke, Annette
Peigneur, Steve
Tytgat, Jan
Wunder, Cora
Mebs, Dietrich
Kauferstein, Silke #
Issue Date: May-2013
Publisher: Multidisciplinary Digital Publishing Institute
Series Title: Toxins vol:5 issue:5 pages:1043-50
Article number: 10.3390/toxins5051043
Abstract: Venoms from cone snails (Conidae) have been extensively studied during the last decades, but those from other members of the suborder Toxoglossa, such as of Terebridae and Turridae superfamilies attracted less interest so far. Here, we report the effects of venom and gland extracts from three species of the superfamily Terebridae. By 2-electrode voltage-clamp technique the gland extracts were tested on Xenopus oocytes expressing nicotinic acetylcholine receptors (nAChRs) of rat neuronal (α3β2, α3β4, α4β2, α4β4, α7) and muscle subtypes (α1β1γδ), and expressing potassium (Kv1.2 and Kv1.3) and sodium channels (Nav1.2, 1.3, 1.4, 1.6). The extracts were shown to exhibit remarkably high inhibitory activities on almost all nAChRs tested, in particular on the α7 subtype suggesting the presence of peptides of the A-superfamily from the venom of Conus species. In contrast, no effects on the potassium and sodium channels tested were observed. The venoms of terebrid snails may offer an additional source of novel biologically active peptides.
ISSN: 2072-6651
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Toxicology and Pharmacology
× corresponding author
# (joint) last author

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