Title: Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis
Authors: Stevens, Marijke ×
Timmermans, Silke
Bottelbergs, Astrid
Hendriks, Jerome J A
Brône, Bert
Baes, Myriam
Tytgat, Jan #
Issue Date: Aug-2013
Publisher: Elsevier/North Holland
Series Title: Journal of Neuroimmunology vol:261 issue:1-2 pages:21-8
Article number: 10.1016/j.jneuroim.2013.04.012
Abstract: Voltage-gated sodium channels (Navs) are involved in several aspects of the pathogenesis of multiple sclerosis (MS). Within acute MS plaques, they are expressed along demyelinated axons. Studies in experimental autoimmune encephalomyelitis (EAE) demonstrated a neuroprotective effect of non-specific Nav blockers. Further, block of specific Navs involved in MS is suggested to have an advantage over non-specific blockers. We investigated the effects of the synthetic Midi peptide in EAE, as it potently and specifically blocks Nav1.2, Nav1.4 and Nav1.6. Administration of this Midi peptide worsens the clinical disease pattern and Nav1.2 and Nav1.6 expression levels were elevated in brain but not in spinal cord of Midi-treated mice, implicating that Navs play a complex role in the pathogenesis of EAE.
ISSN: 0165-5728
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Toxicology and Pharmacology
× corresponding author
# (joint) last author

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