Title: Synthesis and characterization of amino acid deletion analogs of κ-hefutoxin 1, a scorpion toxin on potassium channels
Authors: Peigneur, Steve ×
Yamaguchi, Yoko
Goto, Hitomi
Srinivasan, Kellathur N
Gopalakrishnakone, Ponnampalam
Tytgat, Jan
Sato, Kazuki #
Issue Date: Sep-2013
Publisher: Elsevier
Series Title: Toxicon vol:71 pages:25-30
Article number: 10.1016/j.toxicon.2013.05.010
Abstract: Nine analogs of scorpion toxin peptide κ-hefutoxin 1 were synthesized by stepwise deletion of its amino acid residues. Disulfide bond pairings of the synthetic analogs were confirmed by enzymatic digestion followed by MALDI-TOF-MS measurements. Functional characterization shows that analogs in which N-terminal residues were deleted retained biological activity, whereas deletion of middle part residues resulted in loss of activity. Furthermore, κ-hefutoxin 1 and analogs were subjected to a screening on voltage-gated potassium channels in order to determine their subtype selectivity. It is shown that κ-hefutoxin 1 is suitable as template for peptidomimetics in order to design small peptide-based therapeutic compounds.
ISSN: 0041-0101
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Toxicology and Pharmacology
× corresponding author
# (joint) last author

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