The role of macrophage migration inhibitory factor in anesthetic-induced myocardial preconditioning
Goetzenich, Andreas × Kraemer, Sandra Rossaint, Rolf Bleilevens, Christian Dollo, Florian Siry, Laura Rajabi-Alampour, Setareh Beckers, Christian Soppert, Josefin Lue, Hongqi Rex, Steffen Bernhagen, Jürgen Stoppe, Christian #
Public Library of Sciene
PLoS One vol:9 issue:3 pages:e92827
Anesthetic-induced preconditioning (AIP) is known to elicit cardioprotective effects that are mediated at least in part by activation of the kinases AMPK and PKCε as well as by inhibition of JNK. Recent data demonstrated that the pleiotropic cytokine macrophage migration inhibitory factor (MIF) provides cardioprotection through activation and/or inhibition of kinases that are also known to mediate effects of AIP. Therefore, we hypothesized that MIF could play a key role in the AIP response.