Title: Discovering transcriptional modules from motif, chip-chip and microarray data
Authors: De Bie, T ×
Monsieurs, Pieter
Engelen, Kristof
De Moor, Bart
Cristianini, N
Marchal, Kathleen #
Issue Date: 2005
Host Document: Proceedings of the Pacific Symposium on Biocomputing (PSB 2005) pages:483-494
Conference: Pacific Symposium on Biocomputing location:Hawai date:4-8 january 2005
Abstract: AB - We present a method for inference of transcriptional modules from heterogeneous data sources. It allows identifying the responsible set of regulators in combination with their corresponding DNA recognition sites (motifs) and target genes. Our approach distinguishes itself from previous work in literature because it fully exploits the knowledge of three independently acquired data sources: ChIP-chip data; motif information as obtained by phylogenetic shadowing; and gene expression profiles obtained using microarray experiments. Moreover, these three data sources are dealt with in a new and fully integrated manner. By avoiding approaches that take the different data sources into account sequentially or iteratively, the transparency of the method and the interpretability of the results are ensured. Using our method on biological data demonstrated the biological relevance of the inference
Publication status: published
KU Leuven publication type: IC
Appears in Collections:ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics
Division of Mechatronics, Biostatistics and Sensors (MeBioS)
× corresponding author
# (joint) last author

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