Title: Genome-specific higher-order background models to improve motif detection
Authors: Marchal, Kathleen ×
Thijs, Gert
De Keersmaecker, Sigrid
Monsieurs, Pieter
De Moor, Bart
Vanderleyden, Jozef #
Issue Date: Feb-2003
Publisher: Elsevier Trends Journals
Series Title: Trends in Microbiology vol:11 issue:2 pages:61-66
Abstract: AB - Motif detection based on Gibbs sampling is a common procedure used to retrieve regulatory motifs in silico. Using a species-specific background model was previously shown to increase the robustness of the algorithm. Here, we demonstrate that selecting a non-species-adapted background model can have an adverse effect on the results of motif detection. The large differences in the average nucleotide composition of prokaryotic sequences exacerbate the problem of exchanging background models. Therefore, we have developed complex background models for all prokaryotic species with available genome sequences
ISSN: 0966-842X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Electrical Engineering - miscellaneous
ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics
Centre of Microbial and Plant Genetics
× corresponding author
# (joint) last author

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