Title: Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines
Authors: Temburnikar, Kartik W ×
Zimmermann, Sarah C
Kim, Nathaniel T
Ross, Christina R
Gelbmann, Christopher
Salomon, Christine E
Wilson, Gerald M
Balzarini, Jan
Seley-Radtke, Katherine L #
Issue Date: Apr-2014
Publisher: Pergamon
Series Title: Bioorganic & Medicinal Chemistry vol:22 pages:2113-2122
Article number: S0968-0896(14)00139-4
Abstract: The in vitro evaluation of thieno[3,2-d]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer cell lines. A structure activity relationship study indicated the necessity of the chlorine at the C4-position for biological activity. The two most active compounds 1 and 2 were found to induce apoptosis in the leukemia L1210 cell line. Additionally, the compounds were screened against a variety of other microbial targets and as a result, selective activity against several fungi was also observed. The synthesis and preliminary biological results are reported herein.
ISSN: 0968-0896
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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