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Title: Structure, function and diversity of the healthy human microbiome
Authors: Huttenhower, Curtis ×
Gevers, Dirk
Knight, Rob
Abubucker, Sahar
Badger, Jonathan H
Chinwalla, Asif T
Creasy, Heather H
Earl, Ashlee M
FitzGerald, Michael G
Fulton, Robert S
Giglio, Michelle G
Hallsworth-Pepin, Kymberlie
Lobos, Elizabeth A
Madupu, Ramana
Magrini, Vincent
Martin, John C
Mitreva, Makedonka
Muzny, Donna M
Sodergren, Erica J
Versalovic, James
Wollam, Aye M
Worley, Kim C
Wortman, Jennifer R
Young, Sarah K
Zeng, Qiandong
Aagaard, Kjersti M
Abolude, Olukemi O
Allen-Vercoe, Emma
Alm, Eric J
Alvarado, Lucia
Andersen, Gary L
Anderson, Scott
Appelbaum, Elizabeth
Arachchi, Harindra M
Armitage, Gary
Arze, Cesar A
Ayvaz, Tulin
Baker, Carl C
Begg, Lisa
Belachew, Tsegahiwot
Bhonagiri, Veena
Bihan, Monika
Blaser, Martin J
Bloom, Toby
Bonazzi, Vivien
Brooks, J. Paul
Buck, Gregory A
Buhay, Christian J
Busam, Dana A
Campbell, Joseph L
Canon, Shane R
Cantarel, Brandi L
Chain, Patrick S. G
Chen, I-Min A
Chen, Lei
Chhibba, Shaila
Chu, Ken
Ciulla, Dawn M
Clemente, Jose C
Clifton, Sandra W
Conlan, Sean
Crabtree, Jonathan
Cutting, Mary A
Davidovics, Noam J
Davis, Catherine C
DeSantis, Todd Z
Deal, Carolyn
Delehaunty, Kimberley D
Dewhirst, Floyd E
Deych, Elena
Ding, Yannan
Dooling, David J
Dugan, Shannon P
Dunne, Wm Michael
Durkin, A. Scott
Edgar, Robert C
Erlich, Rachel L
Farmer, Candace N
Farrell, Ruth M
Faust, Karoline
Feldgarden, Michael
Felix, Victor M
Fisher, Sheila
Fodor, Anthony A
Forney, Larry J
Foster, Leslie
Di Francesco, Valentina
Friedman, Jonathan
Friedrich, Dennis C
Fronick, Catrina C
Fulton, Lucinda L
Gao, Hongyu
Garcia, Nathalia
Giannoukos, Georgia
Giblin, Christina
Giovanni, Maria Y
Goldberg, Jonathan M
Goll, Johannes
Gonzalez, Antonio
Griggs, Allison
Gujja, Sharvari
Haake, Susan Kinder
Haas, Brian J
Hamilton, Holli A
Harris, Emily L
Hepburn, Theresa A
Herter, Brandi
Hoffmann, Diane E
Holder, Michael E
Howarth, Clinton
Huang, Katherine H
Huse, Susan M
Izard, Jacques
Jansson, Janet K
Jiang, Huaiyang
Jordan, Catherine
Joshi, Vandita
Katancik, James A
Keitel, Wendy A
Kelley, Scott T
Kells, Cristyn
King, Nicholas B
Knights, Dan
Kong, Heidi H
Koren, Omry
Koren, Sergey
Kota, Karthik C
Kovar, Christie L
Kyrpides, Nikos C
La Rosa, Patricio S
Lee, Sandra L
Lemon, Katherine P
Lennon, Niall
Lewis, Cecil M
Lewis, Lora
Ley, Ruth E
Li, Kelvin
Liolios, Konstantinos
Liu, Bo
Liu, Yue
Lo, Chien-Chi
Lozupone, Catherine A
Lunsford, R. Dwayne
Madden, Tessa
Mahurkar, Anup A
Mannon, Peter J
Mardis, Elaine R
Markowitz, Victor M
Mavromatis, Konstantinos
McCorrison, Jamison M
McDonald, Daniel
McEwen, Jean
McGuire, Amy L
McInnes, Pamela
Mehta, Teena
Mihindukulasuriya, Kathie A
Miller, Jason R
Minx, Patrick J
Newsham, Irene
Nusbaum, Chad
O'Laughlin, Michelle
Orvis, Joshua
Pagani, Ioanna
Palaniappan, Krishna
Patel, Shital M
Pearson, Matthew
Peterson, Jane
Podar, Mircea
Pohl, Craig
Pollard, Katherine S
Pop, Mihai
Priest, Margaret E
Proctor, Lita M
Qin, Xiang
Raes, Jeroen
Ravel, Jacques
Reid, Jeffrey G
Rho, Mina
Rhodes, Rosamond
Riehle, Kevin P
Rivera, Maria C
Rodriguez-Mueller, Beltran
Rogers, Yu-Hui
Ross, Matthew C
Russ, Carsten
Sanka, Ravi K
Sankar, Pamela
Sathirapongsasuti, J. Fah
Schloss, Jeffery A
Schloss, Patrick D
Schmidt, Thomas M
Scholz, Matthew
Schriml, Lynn
Schubert, Alyxandria M
Segata, Nicola
Segre, Julia A
Shannon, William D
Sharp, Richard R
Sharpton, Thomas J
Shenoy, Narmada
Sheth, Nihar U
Simone, Gina A
Singh, Indresh
Smillie, Christopher S
Sobel, Jack D
Sommer, Daniel D
Spicer, Paul
Sutton, Granger G
Sykes, Sean M
Tabbaa, Diana G
Thiagarajan, Mathangi
Tomlinson, Chad M
Torralba, Manolito
Treangen, Todd J
Truty, Rebecca M
Vishnivetskaya, Tatiana A
Walker, Jason
Wang, Lu
Wang, Zhengyuan
Ward, Doyle V
Warren, Wesley
Watson, Mark A
Wellington, Christopher
Wetterstrand, Kris A
White, James R
Wilczek-Boney, Katarzyna
Wu, YuanQing
Wylie, Kristine M
Wylie, Todd
Yandava, Chandri
Ye, Liang
Ye, Yuzhen
Yooseph, Shibu
Youmans, Bonnie P
Zhang, Lan
Zhou, Yanjiao
Zhu, Yiming
Zoloth, Laurie
Zucker, Jeremy D
Birren, Bruce W
Gibbs, Richard A
Highlander, Sarah K
Methe, Barbara A
Nelson, Karen E
Petrosino, Joseph F
Weinstock, George M
Wilson, Richard K
White, Owen #
Issue Date: Jun-2012
Publisher: Nature Publishing Group
Series Title: Nature vol:486 issue:7402 pages:207-214
Abstract: Studies of the human microbiome have revealed that even healthy individuals differ remarkably in the microbes that occupy habitats such as the gut, skin and vagina. Much of this diversity remains unexplained, although diet, environment, host genetics and early microbial exposure have all been implicated. Accordingly, to characterize the ecology of human-associated microbial communities, the Human Microbiome Project has analysed the largest cohort and set of distinct, clinically relevant body habitats so far. We found the diversity and abundance of each habitat's signature microbes to vary widely even among healthy subjects, with strong niche specialization both within and among individuals. The project encountered an estimated 81-99% of the genera, enzyme families and community configurations occupied by the healthy Western microbiome. Metagenomic carriage of metabolic pathways was stable among individuals despite variation in community structure, and ethnic/racial background proved to be one of the strongest associations of both pathways and microbes with clinical metadata. These results thus delineate the range of structural and functional configurations normal in the microbial communities of a healthy population, enabling future characterization of the epidemiology, ecology and translational applications of the human microbiome.
URI: 
ISSN: 0028-0836
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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