Title: Caspase deficiency alters the murine gut microbiome
Authors: Brinkman, B. M ×
Hildebrand, F
Kubica, M
Goosens, D
Del Favero, J
Declercq, W
Raes, Jeroen
Vandenabeele, P #
Issue Date: Oct-2011
Publisher: Nature Publishing Group
Series Title: Cell Death & Disease vol:2
Article number: e220
Abstract: Caspases are aspartate-specific cysteine proteases that have an essential role in apoptosis and inflammation, and contribute to the maintenance of homeostasis in the intestine. These facts, together with the knowledge that caspases are implicated in host-microbe crosstalk, prompted us to investigate the effect of caspase (Casp)1, -3 and -7 deficiency on the composition of the murine gut microbiota. We observed significant changes in the abundance of the Firmicutes and Bacteroidetes phyla, in particular the Lachnospiraceae, Porphyromonodaceae and Prevotellacea families, when comparing Casp-1, -7 and -3 knockout mice with wild-type mice. Our data point toward an intricate relationship between these caspases and the composition of the murine gut microflora.
ISSN: 2041-4889
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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