Title: Enterotypes of the human gut microbiome
Authors: Arumugam, Manimozhiyan ×
Raes, Jeroen
Pelletier, Eric
Le Paslier, Denis
Yamada, Takuji
Mende, Daniel R
Fernandes, Gabriel R
Tap, Julien
Bruls, Thomas
Batto, Jean-Michel
Bertalan, Marcelo
Borruel, Natalia
Casellas, Francesc
Fernandez, Leyden
Gautier, Laurent
Hansen, Torben
Hattori, Masahira
Hayashi, Tetsuya
Kleerebezem, Michiel
Kurokawa, Ken
Leclerc, Marion
Levenez, Florence
Manichanh, Chaysavanh
Nielsen, H Bjørn
Nielsen, Trine
Pons, Nicolas
Poulain, Julie
Qin, Junjie
Sicheritz-Ponten, Thomas
Tims, Sebastian
Torrents, David
Ugarte, Edgardo
Zoetendal, Erwin G
Wang, J
Guarner, Francisco
Pedersen, Oluf
de Vos, Willem M
Brunak, Søren
Doré, Joel
Weissenbach, Jean
MetaHIT Consortium
Ehrlich, S. Dusko
Antolín, María
Bork, Peer #
Artiguenave, François
Blottiere, Hervé M
Almeida, Mathieu
Brechot, Christian
Cara, Carlos
Chervaux, Christian
Cultrone, Antonella
Delorme, Christine
Denariaz, Gérard
Dervyn, Rozenn
Foerstner, Konrad U
Friss, Carsten
van de Guchte, Maarten
Guedon, Eric
Haimet, Florence
Huber, Wolfgang
van Hylckama-Vlieg, Johan
Jamet, Alexandre
Juste, Catherine
Kaci, Ghalia
Knol, Jan
Lakhdari, Omar
Layec, Severine
Le Roux, Karine
Maguin, Emmanuelle
Mérieux, Alexandre
Melo Minardi, Raquel
M'rini, Christine
Muller, Jean
Oozeer, Raish
Parkhill, Julian
Renault, Pierre
Rescigno, Maria
Sanchez, Nicolas
Sunagawa, Shinichi
Torrejon, Antonio
Turner, Keith
Vandemeulebrouck, Gaetana
Varela, Encarna
Winogradsky, Yohanan
Zeller, Georg
Ehrlich, S Dusko
Issue Date: May-2011
Publisher: Nature Publishing Group
Series Title: Nature vol:473 issue:7346 pages:174-180
Article number: 10.1038/nature09944
Abstract: Our knowledge of species and functional composition of the human gut microbiome is rapidly increasing, but it is still based on very few cohorts and little is known about variation across the world. By combining 22 newly sequenced faecal metagenomes of individuals from four countries with previously published data sets, here we identify three robust clusters (referred to as enterotypes hereafter) that are not nation or continent specific. We also confirmed the enterotypes in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous. This indicates further the existence of a limited number of well-balanced host-microbial symbiotic states that might respond differently to diet and drug intake. The enterotypes are mostly driven by species composition, but abundant molecular functions are not necessarily provided by abundant species, highlighting the importance of a functional analysis to understand microbial communities. Although individual host properties such as body mass index, age, or gender cannot explain the observed enterotypes, data-driven marker genes or functional modules can be identified for each of these host properties. For example, twelve genes significantly correlate with age and three functional modules with the body mass index, hinting at a diagnostic potential of microbial markers.
ISSN: 0028-0836
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science