Title: A human gut microbial gene catalogue established by metagenomic sequencing
Authors: Qin, Junjie ×
Li, Ruiqiang
Raes, Jeroen
Arumugam, Manimozhiyan
Burgdorf, Kristoffer Solvsten
Manichanh, Chaysavanh
Nielsen, Trine
Pons, Nicolas
Levenez, Florence
Yamada, Takuji
Mende, Daniel R
Li, Junhua
Xu, Junming
Li, Shaochuan
Li, Dongfang
Cao, Jianjun
Wang, Bo
Liang, Huiqing
Zheng, Huisong
Xie, Yinlong
Tap, Julien
Lepage, Patricia
Bertalan, Marcelo
Batto, Jean-Michel
Hansen, Torben
Le Paslier, Denis
Linneberg, Allan
Nielsen, H. Bjorn
Pelletier, Eric
Renault, Pierre
Sicheritz-Ponten, Thomas
Turner, Keith
Zhu, Hongmei
Yu, Chang
Li, Shengting
Jian, Min
Zhou, Yan
Li, Yingrui
Zhang, Xiuqing
Li, Songgang
Qin, Nan
Yang, Huanming
Wang, Jian
Brunak, Soren
Dore, Joel
Guarner, Francisco
Kristiansen, Karsten
Pedersen, Oluf
Parkhill, Julian
Weissenbach, Jean
Bork, Peer
MetaHIT Consortium
Ehrlich, S. Dusko
Wang, J #
Issue Date: Mar-2010
Publisher: Nature Publishing Group
Series Title: Nature vol:464 issue:7285 pages:59-65
Article number: 10.1038/nature08821
Abstract: To understand the impact of gut microbes on human health and well-being it is crucial to assess their genetic potential. Here we describe the Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals. The gene set, approximately 150 times larger than the human gene complement, contains an overwhelming majority of the prevalent (more frequent) microbial genes of the cohort and probably includes a large proportion of the prevalent human intestinal microbial genes. The genes are largely shared among individuals of the cohort. Over 99% of the genes are bacterial, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species, which are also largely shared. We define and describe the minimal gut metagenome and the minimal gut bacterial genome in terms of functions present in all individuals and most bacteria, respectively.
ISSN: 0028-0836
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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