The Journal of Clinical Endocrinology & Metabolism vol:92 issue:8 pages:3330-3333
Context. Critical illness is associated with the 'low T3 syndrome'. It remains unclear whether altered type II deiodinase activity (D2) in skeletal muscle contributes to this syndrome. Objective. To study D2 expression and activity in skeletal muscle of acute and prolonged critically ill patients. Design. A clinical observational study in acute and prolonged critical illness with comparison to healthy controls. Setting. A university hospital surgical intensive care unit and a university animal laboratory. Patients. Sixty-three prolonged critically ill patients who died in ICU, 21 acutely ill patients and 38 controls matched for age, gender and BMI. Results. Elevated expression of the D2 gene and D2 activity in skeletal muscle of prolonged, but not acute, critically ill patients were observed in the face of low circulating thyroid hormone levels. Conclusions. Reduced D2 activity does not appear to play a role in the pathogenesis of the low T3 syndrome of critical illness.