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Title: A Novel Translational Model of Percutaneous Fetoscopic Endoluminal Tracheal Occlusion - Baboons ( Papio spp.)
Authors: Mari, Giancarlo × Deprest, Jan Schenone, Mauro Jackson, Scott Samson, Jacques Brocato, Brian Tate, Danielle Sullivan, Ryan White, Garry Dhanireddy, Reddy Mandrell, Timothy Gupta, Sonali Skobowjat, Cezary Slominski, Andrzej Cohen, Harris L Schlabritz-Loutsevitch, Natalia #
Issue Date: 30-Jan-2014
Publisher: S. Karger
Series Title: Fetal Diagnosis and Therapy vol:35 issue:2 pages:92-100
Article number: 10.1159/000357139
Abstract: Introduction: Percutaneous fetoscopic endoluminal reversible tracheal occlusion (FETO) was developed to prevent the pulmonary complications of fetal congenital diaphragmatic herniation. There is an urgent need to establish the closest to human translational model of FETO in order to improve fetal outcomes and to determine new clinical approaches and applications. Material and Methods: Seven non-human primates underwent two subsequent surgeries: the first, the FETO in the experimental group (n = 3) or sham operation in the control animals (S-FETO, n = 4) at 132-142 days of gestation (dGA); the second, the reversal of occlusion or sham operation at 162 ± 5 dGA. Maternal stress axis, complete blood count, and biochemical parameters were evaluated and newborn tracheal radiography was performed. Results: The average pregnancy duration and neonatal weights in the FETO group did not differ from the animals in the S-FETO group. There was no bleeding or premature fetal membrane rupture during the procedures in any of the baboons. The maximal tracheal width was 7.02 ± 0.6 mm in the FETO versus 5.46 ± 0.6 mm in S-FETO group. Discussion: This is the very first report of a successful FETO model in non-human primates. Similarities to human tracheomegaly were for the first time documented in any model studied. © 2014 S. Karger AG, Basel.
Publication status: published
KU Leuven publication type: IT
Appears in Collections: Organ Systems (+)
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