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Title: Addressing diagnostic challenges in primary immunodeficiencies: Laboratory evaluation of Toll-like receptor- and NF-κB-mediated immune responses
Authors: Frans, Glynis ×
Meyts, Isabelle
Picard, Capucine
Puel, Anne
Zhang, Shen-Ying
Moens, Leen
Wuyts, Greet
Van der Werff Ten Bosch, Jutte
Casanova, Jean-Laurent
Bossuyt, Xavier #
Issue Date: Apr-2014
Publisher: CRC Press
Series Title: Critical Reviews in Clinical Laboratory Sciences vol:51 issue:2 pages:112-23
Abstract: Abstract Toll-like receptors (TLRs) play an important role in immunity and mediate their actions via multiple signaling pathways, in particular, the nuclear factor of kappa light polypeptide gene enhancer in B-cells (NF-κB) pathway. Rare inherited defects of TLR- and NF-κB-dependent responses have recently been recognized. These primary immunodeficiencies predispose children to life-threatening infections and often remain undiagnosed. Establishing a sensitive, specific, cost-effective and simple method for diagnosis is therefore important. In this article, we review the known defects of TLR- and NF-κB-mediated pathways and the assays that can be used to screen for such defects.
URI: 
ISSN: 1040-8363
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical Bacteriology and Mycology
× corresponding author
# (joint) last author

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