Schizophrenia genetic variants are not associated with intelligence
van Scheltinga, A F Terwisscha × Bakker, S C van Haren, N E M Derks, E M Buizer-Voskamp, J E Cahn, W Ripke, S Psychiatric Genome-Wide Association Study (GWAS) Consortium Ophoff, R A Kahn, R S De Hert, Marc #
Psychological Medicine vol:43 issue:12 pages:2563-2570
Schizophrenia is associated with lower pre-morbid intelligence (IQ) in addition to (pre-morbid) cognitive decline. Both schizophrenia and IQ are highly heritable traits. Therefore, we hypothesized that genetic variants associated with schizophrenia, including copy number variants (CNVs) and a polygenic schizophrenia (risk) score (PSS), may influence intelligence.