Title: Delta-9-Tetrahydrocannabinol-Induced Dopamine Release as a Function of Psychosis Risk: F-18-Fallypride Positron Emission Tomography Study
Authors: Kuepper, Rebecca ×
Ceccarini, Jenny
Lataster, Johan
van Os, Jim
van Kroonenburgh, Marinus
van Gerven, Joop M. A
Marcelis, Machteld
Van Laere, Koen
Henquet, Cecile #
Issue Date: 2013
Publisher: Public Library of Sciene
Series Title: PLoS One vol:8 issue:7 pages:e70378-e70378
Abstract: Cannabis use is associated with psychosis, particularly in those with expression of, or vulnerability for, psychotic illness. The biological underpinnings of these differential associations, however, remain largely unknown. We used Positron Emission Tomography and (18)F-fallypride to test the hypothesis that genetic risk for psychosis is expressed by differential induction of dopamine release by Δ(9)-THC (delta-9-tetrahydrocannabinol, the main psychoactive ingredient of cannabis). In a single dynamic PET scanning session, striatal dopamine release after pulmonary administration of Δ(9)-THC was measured in 9 healthy cannabis users (average risk psychotic disorder), 8 patients with psychotic disorder (high risk psychotic disorder) and 7 un-related first-degree relatives (intermediate risk psychotic disorder). PET data were analyzed applying the linear extension of the simplified reference region model (LSRRM), which accounts for time-dependent changes in (18)F-fallypride displacement. Voxel-based statistical maps, representing specific D2/3 binding changes, were computed to localize areas with increased ligand displacement after Δ(9)-THC administration, reflecting dopamine release. While Δ(9)-THC was not associated with dopamine release in the control group, significant ligand displacement induced by Δ(9)-THC in striatal subregions, indicative of dopamine release, was detected in both patients and relatives. This was most pronounced in caudate nucleus. This is the first study to demonstrate differential sensitivity to Δ(9)-THC in terms of increased endogenous dopamine release in individuals at risk for psychosis.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Nuclear Medicine & Molecular Imaging
× corresponding author
# (joint) last author

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