Journal of Flow Chemistry
Author:
Keywords:
CO-free, carbonylation, Flow chemistry, aryl formate, palladium, Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, flow chemistry, PALLADIUM-CATALYZED CARBONYLATION, KHAND-TYPE REACTION, N-FORMYLSACCHARIN, HALIDES, REACTORS, AMINOCARBONYLATION, CHEMISTRY, ALDEHYDES, EFFICIENT, ALKENYL, 0305 Organic Chemistry, 3405 Organic chemistry
Abstract:
© 2014 Akadémiai Kiadó. The first continuous flow carbonylation reaction using aryl formates as CO precursor is reported. The reaction is practical, scalable and high yielding. The use of a flow protocol safely allows expanding the scope to activated chlorides, nitrogen heterocycles and to the selective introduction of an ester group in dihalo-derivatives. Further selective reduction of the ester formed to an aldehyde in flow is also described.