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Title: Influence of time delay on the estimated lung shunt fraction on 99mTc-labeled MAA scintigraphy for 90Y microsphere treatment planning
Authors: De Gersem, Ruth ×
Maleux, Geert
Vanbilloen, Hubert
Baete, Kristof
Verslype, Chris
Haustermans, Karin
Verbruggen, Alfons
Van Cutsem, Eric
Deroose, Christophe #
Issue Date: Dec-2013
Publisher: Lippincott
Series Title: Clinical Nuclear Medicine vol:38 issue:12 pages:940-2
Article number: 10.1097/RLU.0000000000000241
Abstract: 90Y-microspheres therapy is used to treat selected patients with primary or metastatic liver tumors in a safe and effective way. As a preparation for 90Y-microspheres treatment, a 99mTc-macroaggregated albumin (99mTc-MAA) simulation procedure is essential to evaluate particle shunting to the lung or gastrointestinal tract. We investigated the effect of interval between injection of 99mTc-MAA and time of scanning on the lung shunt fraction (LSF). In 4 patients with secondary hepatic malignancies who underwent repeated whole-body scintigraphy up to 5 hours after injection of 99mTc-MAA, a marked change in LSF was observed. It appears that tracer degradation leads to an important overestimation of LSF at later time points. An overestimation of LSF can lead to dose reduction or canceling of the planned 90Y-microspheres treatment. It is concluded that the interval between injection and scanning should be kept as short as possible.
ISSN: 0363-9762
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Nuclear Medicine & Molecular Imaging
Hepatology
Department of Health and Technology - UC Leuven
Laboratory of Experimental Radiotherapy
Radiopharmacy
Clinical Digestive Oncology (+)
Radiology
× corresponding author
# (joint) last author

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