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Title: Integrating influenza antigenic dynamics with molecular evolution
Authors: Bedford, Trevor ×
Suchard, Marc A
Lemey, Philippe
Dudas, Gytis
Gregory, Victoria
Hay, Alan J
McCauley, John W
Russell, Colin A
Smith, Derek J
Rambaut, Andrew #
Issue Date: 2014
Publisher: eLife Sciences
Series Title: Elife vol:3 pages:e01914
Article number: 10.7554/eLife.01914
Abstract: Influenza viruses undergo continual antigenic evolution allowing mutant viruses to evade host immunity acquired to previous virus strains. Antigenic phenotype is often assessed through pairwise measurement of cross-reactivity between influenza strains using the hemagglutination inhibition (HI) assay. Here, we extend previous approaches to antigenic cartography, and simultaneously characterize antigenic and genetic evolution by modeling the diffusion of antigenic phenotype over a shared virus phylogeny. Using HI data from influenza lineages A/H3N2, A/H1N1, B/Victoria and B/Yamagata, we determine patterns of antigenic drift across viral lineages, showing that A/H3N2 evolves faster and in a more punctuated fashion than other influenza lineages. We also show that year-to-year antigenic drift appears to drive incidence patterns within each influenza lineage. This work makes possible substantial future advances in investigating the dynamics of influenza and other antigenically-variable pathogens by providing a model that intimately combines molecular and antigenic evolution. DOI: http://dx.doi.org/10.7554/eLife.01914.001.
URI: 
ISSN: 2050-084X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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